Updated Jan 31, 2021

An effective PZA resistance assay to reduce drug side effects and improve treatment adherence.

http://www.upch.edu.pe/portal/

Roberto Alcantara

These innovators propose to design an effective, fast and reproducible test to determine PZA resistance.
How does your innovation work?
It is important to determine PZA susceptibility in the early stages of treatment to provide a safe regimen and to improve adherence, but PZA-susceptibility assays are not adequate and lack reproducibility. These innovators propose to design a test to dete...
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These innovators propose to design an effective, fast and reproducible test to determine PZA resistance.
How does your innovation work?
It is important to determine PZA susceptibility in the early stages of treatment to provide a safe regimen and to improve adherence, but PZA-susceptibility assays are not adequate and lack reproducibility. These innovators propose to design a test to determine PZA resistance. Based on our previous studies, the rate at which pyrazinoic acid (POA) is extruded from the bacteria is an accurate biomarker of PZA resistance. The ultimate goal is an automatic machine for measuring PZA resistance.
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Stage 2: Research & Development

There are a few reasons why the treatment of tuberculosis (TB) can fail. One of them is the lack of adherence to the DOTS strategy (directly observed treatment, short-course, recommended by the World Health Organization). The absence of fast recovery and adverse effects are commonly associated to treatment drop-out. As a result, Multi-Drug Resistant TB is emerging. Pyrazinamide (PZA), the only drug effective against latent TB, produces serious hepatic side effects.
Registered in Peruin Peru

Focus Areas:

Health

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Implemented In:

Peru

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1
Country Implemented In
Verified Funding
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Planned Goals and Milestones

This project is funded under a collaborative agreement between CONCYTEC (Peru’s National Council for Science, Technology and Technological Innovation) and 49 to support 1433 innovators based in Peru.

Milestone

Oct 2014
Date Unknown
Created
Date Unknown
New Country Implemented In
Peru