Updated Apr 17, 2018CLOSED

Grand Challenges Africa: New Approaches to Characterize the Global Burden of Antimicrobial Resistance

Offered by African Academy of Sciences, Bill & Melinda Gates Foundation and New Partnership for Africa's Development as part of Alliance for Accelerating Excellence in Science in Africa and Grand Challenges Africa

Appropriate antibiotic use has the power to save lives in the most vulnerable communities, and antimicrobial resistance (AMR) impacts multiple global health priority areas: HIV/AIDS, tuberculosis, maternal and neonatal health, pneumonia, and enteric and diarrheal diseases.We seek new approaches that have the potential to transform public health action on a regional or global scale by identifying and filling gaps in knowledge on the burden of resistance to antibacterial agents – we are not seeking incremental improvements in typical disease surveillance solutions.
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CLOSEDMay 16, 2018Deadline
Up to $250,000Amount
Criteria: LabelCriteria: DescriptionAmount Per Prize
Grant CategorySeed GrantsUp to $100,000
Grant CategoryInnovation Transition GrantsUp to $250,000

Mandatory Requirements

StageStage 2: Research & Development, Stage 3: Proof of Concept and Stage 4: Transition to Scale
Implemented In:
Focus AreasHealth

Specifically, we seek projects that propose innovation in the following areas:

Data sources: Pilot tests of new sources of data, particularly those that would bring together different research communities for new perspectives on the problem
Analytical methods: Pilot tests of bioinformatics approaches, including those that combine or connect existing databases in novel ways
Biomarkers: Pilot tests of new biomarkers or combinations of biomarkers that could lead to new understanding of the actionable implications of antimicrobial resistance surveillance data
Low-cost technologies and products: Exploratory work in developing new technologies and products, including 1) those that specifically target improved infection prevention and control in healthcare settings to reduce reliance on healthcare provider behavior change, and 2) technologies to remove antibiotics from effluents.

Specific examples of projects that the challenge is looking for can be foundhere

Other Requirements

Management TeamAfrican investigators are invited to apply, with the support of the primary organization where they are affiliated, and where the major programme of work will be undertaken.
Past Impact Evaluation
Seed grants (funded at up to $100,000 USD) do not require extensive preliminary data and are meant to provide an opportunity to test particularly bold ideas, including applying approaches from outside the field or that bridge fields. New approaches could be piloted as additions to ongoing funded projects. The application process entails submission of an online application succinctly describing the new approach and how it will be tested.

Full grants – Open to South African Nationals only (funded at up to $250,000 USD) do require substantial preliminary data and are meant to provide an opportunity to refine and rigorously test approaches, including those that have previously shown promise in controlled or limited settings.
OtherWe will NOT consider funding for:
-Proposals to develop diagnostic devices and technologies or for drug discovery. Although diagnostic devices and new drugs are potentially critical to AMR solutions, these areas are not unique to AMR challenges and should therefore be advanced more comprehensively against a broader landscape of possible needs and solutions. Thus, while excluded here, they may be part of a future request for proposals.
-Proposals without a clear application to surveillance or facilitating the development of new evidence describing the global burden of AMR
-Proposals seeking to apply existing tools in ways that do not transform our understanding of the global emergence or spread of AMR
-Incremental improvements to conventional solutions or typical disease surveillance. We will not consider local surveillance programs or projects or small improvements in surveillance, e.g., use of mobile data collection, automation of traditional processes, or improving access to existing tools or technologies.
-Proposals that simply expand the availability of primary data without a clear link to informing our understanding of global AMR epidemiology
-Applications proposing basic research
-Ideas not directly relevant to low- and middle-income contexts
-Genomic and other laboratory-based approaches that lack a clear application to AMR surveillance or epidemiology
-Ideas focused on quantifying resistance in animal or livestock populations or in environmental samples without a direct linkage to how data would impact public health practice
-Proposals involving clinical trials in human volunteers or patients (note: use of existing datasets or other outputs from clinical trials may be considered, as long as the proposed approach is feasible within the time and financial envelopes provided).

This request for proposals seeks to encourage scientific collaborations between African researchers, and between different organizations across the continent. We therefore seek to encourage data sharing between individually funded projects. We expect that such sharing will help to ensure that the goals of the innovative approaches in individual projects are ultimately integrated with each other. Furthermore, we expect that sharing experimental methods, data, and resources will ultimately improve the ability to compare and validate local research findings and to develop innovations, interventions and products that can have impact at a greater scale. The reviewers to this call will evaluate how well applications address these requirements. Collaborative efforts include:
-Cohort harmonization: when collaborating with projects with existing cohorts or establishing new cohorts, investigators will be expected to participate, whenever possible, in cohort harmonization. Study sites will be expected to develop and follow standard operating procedures and quality control protocols for specimen collections and participate in the establishment of a minimum common set of data and specimens to be collected across the program.
-Data sharing: Projects will submit a data sharing plan that is equitable, ethical, and efficient.

Application Directions

Please submit a two page concept note on theGrand Challenges Africa/South Africa Portal.For additional guidance please refer to the attached document, "Guidance for Submitting an application or Nomination in AAS Ishango Online System

Application And Awards Process

Additional onlineFAQsabout the application process.


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